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VIRIONZA is an inactivated, split-virion influenza vaccine designed to prevent influenza caused by specific Influenza A and B virus strains recommended by the World Health Organization (WHO). It is a split-virion vaccine, meaning the virus particles are chemically disrupted, purified, and inactivated, which reduces reactogenicity (side effects) while maintaining key antigens (haemagglutinin) that stimulate the immune system. 

Product Characteristics

• Vaccine Type: Inactivated, split-virion, trivalent or quadrivalent (based on seasonal formulation).
• Composition: Contains 15µg of hemagglutinin for each strain (typically two A subtypes and one or two B types).
• Preparation: Cultured in chicken embryos, then split and inactivated using beta-propiolactone.
• Appearance: Colorless or slightly opalescent, whitish liquid.
• Preservative: Some formulations may be preservative-free, while others contain thiomersal. 

Indications & Usage

• Purpose: Prophylaxis of influenza, particularly for high-risk populations.
• Age Range: Approved for adults and children, typically from 6 months of age and older (varies by formulation, sometimes 3 years+).
• Administration: Intramuscular injection, usually in the deltoid muscle.
• Dosage: A single 0.5 mL dose is standard for adults and children over 3, with a 0.25 mL or 0.5 mL dose for younger children depending on prior vaccination status. 

Storage & Stability

• Temperature: Store in a refrigerator at 2°C – 8°C.
• Handling: Do not freeze. Protect from light.
• Shelf Life: Generally 12 months, with 28 days for open multi-dose vials. 

Key Features & Safety

• No Live Virus: The vaccine is inactivated, so it cannot cause influenza.
• Side Effects: Common reactions include pain at the injection site, fever, headache, muscle pain, and fatigue.
• Contraindications: Severe allergic reaction (anaphylaxis) to a previous dose or components like egg protein, neomycin, or formaldehyde. 

Disclaimer: This information is based on standard specifications for split-virion influenza vaccines. Specific details may vary based on the manufacturer (e.g., Sinovac) and the specific, seasonally updated product insert.